Publication:
Extramitochondrial Assembly of Mitochondrial Targeting Signal Disrupted Mitochondrial Enzyme Aldehyde Dehydrogenase

Issued Date

2018-12-01

Resource Type

Article

ISSN

20452322

DOI

10.1038/s41598-018-24586-7

Other identifier(s)

2-s2.0-85045695431

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Scientific Reports. Vol.8, No.1 (2018)

Suggested Citation

Chalongrat Noree Extramitochondrial Assembly of Mitochondrial Targeting Signal Disrupted Mitochondrial Enzyme Aldehyde Dehydrogenase. Scientific Reports. Vol.8, No.1 (2018). doi:10.1038/s41598-018-24586-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47461

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Title

Extramitochondrial Assembly of Mitochondrial Targeting Signal Disrupted Mitochondrial Enzyme Aldehyde Dehydrogenase

Author(s)

Chalongrat Noree

Other Contributor(s)

Mahidol University

Abstract

© 2018 The Author(s). Supramolecular assembly of metabolic enzymes has been studied both in vivo and in vitro for nearly a decade. Experimental evidence has suggested a close relationship between enzymatic activity and enzyme assembly/disassembly. However, most cases were studied with the cytosolic enzymes. Here, I report the evidence for a mitochondrial enzyme with its ability in forming visible intracellular structures. By removing the mitochondrial targeting sequence, yeast mitochondrial enzyme aldehyde dehydrogenase (Ald4p) exhibits reversible supramolecular assembly in the cytoplasm, thus creating a useful system for further characterization of the regulatory factors that modulate the assembly/disassembly of this mitochondrial enzyme.

Keyword(s)

Multidisciplinary

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/47461

Collections

Scopus 2018