Publication: Sexual transmission of XMRV: A potential infection route
Issued Date
2011-12-01
Resource Type
ISSN
16878647
16878639
16878639
Other identifier(s)
2-s2.0-84867300903
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Mahidol University
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SCOPUS
Bibliographic Citation
Advances in Virology. Vol.2011, (2011)
Suggested Citation
Prachi Sharma, Kenneth A. Rogers, Suganthi Suppiah, Ross J. Molinaro, Nattawat Onlamoon, John Hackett, Gerald Schochetman, Eric A. Klein, Robert H. Silverman, François Villinger Sexual transmission of XMRV: A potential infection route. Advances in Virology. Vol.2011, (2011). doi:10.1155/2011/965689 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11961
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Title
Sexual transmission of XMRV: A potential infection route
Abstract
Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, all infected macaques exhibited readily detectable XMRV signal in the reproductive tract of all 4 males and 1 female during both acute and chronic infection stages. XMRV showed explosive growth in the acini of prostate during acute but not chronic infection. In seminal vesicles, epididymis, and testes, XMRV protein production was detected throughout infection in interstitial or epithelial cells. In the female monkey, epithelial cells in the cervix and vagina were also positive for XMRV gag. The ready detection of XMRV in the reproductive tract of male and female macaques infected intravenously suggests the potential for sexual transmission for XMRV. © 2011 Prachi Sharma et al.