Publication: Neutralizing dengue antibody in pregnant Thai women and cord blood.
Accepted Date
2014-11-05
Issued Date
2015-02-06
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eng
ISSN
1935-2735 (electronic)
1935-2727 (printed)
1935-2727 (printed)
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Mahidol University
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PubMed Central
Bibliographic Citation
Khamim K, Hattasingh W, Nisalak A, Kaewkungwal J, Fernandez S, Thaisomboonsuk B, et al. Neutralizing dengue antibody in pregnant Thai women and cord blood. PLoS Negl Trop Dis. 2015 Feb 6;9(2):e0003396.
Suggested Citation
Kriangsak Khamim, เกรียงศักดิ์ คำอิ่ม, Weerawan Hattasingh, วีรวรรณ หัตถสิงห์, Ananda Nisalak, Jaranit Kaewkungwal, จรณิต แก้วกังวาล, Fernandez, Stefan, Butsaya Thaisomboonsuk, บุษยา ไทยสมบูรณ์สุข, Krisana Pengsaa, กฤษณา เพ็งสา, Usa Thisyakorn, อุษา ทิสยากร Neutralizing dengue antibody in pregnant Thai women and cord blood.. Khamim K, Hattasingh W, Nisalak A, Kaewkungwal J, Fernandez S, Thaisomboonsuk B, et al. Neutralizing dengue antibody in pregnant Thai women and cord blood. PLoS Negl Trop Dis. 2015 Feb 6;9(2):e0003396.. doi:10.1371/journal.pntd.0003396. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/797
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Title
Neutralizing dengue antibody in pregnant Thai women and cord blood.
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Abstract
BACKGROUND: The WHO 'Global Strategy for Dengue Prevention and Control,
2012-2020' addresses the growing need for the treatment of dengue, and targets a
25% reduction in morbidity and 50% in mortality (using 2010 estimates as
baseline). Achieving these goals requires future dengue prevention strategies
that will employ both potential vaccines and sustainable vector-control measures.
Maternally transferred dengue antibody is an important factor in determining the
optimal age for dengue vaccination.
OBJECTIVES: To estimate the seroprevalence of dengue antibodies among mothers
living in an area of high endemicity--Ban Pong, Ratchaburi Province--and to
assess maternal dengue antibodies transferred to cord blood.
MATERIALS & METHODS: A cross-sectional study was conducted with 141 pregnant
women who delivered at Ban Pong Hospital, Ratchaburi, Thailand. Maternal-cord
paired sera were tested for dengue neutralizing (NT) antibody by PRNT50 assay. A
ratio of ≥ 1:10 NT titer to dengue serotype was considered seropositive.
RESULTS: Most mothers (137/141, 97.2%) had NT antibodies to at least one dengue
serotype in their sera. At birth, the proportion of cord sera with NT antibodies
to DEN-1, DEN-2, DEN-3, and DEN-4, were high and similar to the sera of their
mothers, at 93.6%, 97.2%, 97.9%, and 92.2%, respectively. The dengue geometric
mean titers (GMT) in cord blood were significantly higher than the maternal
antibodies (p<0.001): highest in DEN-2, followed by DEN-3, and then DEN-1. The
GMT of DEN-4 was the lowest among all four serotypes.
CONCLUSIONS: Dengue infection is highly prevalent among pregnant women in this
dengue-endemic area. Most of the cord blood had transferred dengue antibodies,
which may have an impact on the disease burden in this population.