Publication: Impact of glycemic variability and hypoglycemia on adverse hospital outcomes in non-critically ill patients
Issued Date
2014-01-01
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ISSN
18728227
01688227
01688227
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2-s2.0-84898866458
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Mahidol University
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SCOPUS
Bibliographic Citation
Diabetes Research and Clinical Practice. Vol.103, No.3 (2014), 437-443
Suggested Citation
Yoojin Kim, Kumar B. Rajan, Shannon A. Sims, Kristen E. Wroblewski, Sirimon Reutrakul Impact of glycemic variability and hypoglycemia on adverse hospital outcomes in non-critically ill patients. Diabetes Research and Clinical Practice. Vol.103, No.3 (2014), 437-443. doi:10.1016/j.diabres.2013.11.026 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33442
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Title
Impact of glycemic variability and hypoglycemia on adverse hospital outcomes in non-critically ill patients
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Abstract
Aims: To determine if glycemic variability is associated with hospitalization outcomes in non-critically ill patients, and if this association remains after controlling for hypoglycemia. Methods: A retrospective review was performed on 1276 medical admissions (801 patients) in which insulin was given, ≥6 point of care glucose (POCG) measurements and length of stay (LOS) 2-30 days. Coefficient of variation (%CV) was used to measure glycemic variability. Outcomes included LOS and a composite outcome based on ICU transfer, hospital acquired infections, and acute renal failure (ARF). Results: There were a median of 18.5 POCG measurements per admission with a mean %CV 34.2. ±. 11.1. Hypoglycemia (POCG ≤70. mg/dl [3.9. mmol/l]) occurred in 35.0% of admissions. ICU transfer occurred in 3.3%, hospital acquired infections 4.8%, ARF 8.3%, and composite outcome 13.5%. Adjusting for age, sex, race and Charlson score, every 10 unit increase in %CV was associated with an increase in LOS of 0.27 days (p= 0.004), while there was no association between %CV and the composite outcome. For LOS, there was a significant interaction between %CV and hypoglycemia (p= 0.07). While there was a non-significant correlation in patients without hypoglycemia, LOS correlated negatively with %CV in patients with hypoglycemia. When considered simultaneously with %CV, hypoglycemia was associated with increased odds of the composite outcome [OR 2.03 (95% CI 1.36-3.01), p= <0.001] and an increase of 2 days in LOS for those with average %CV. Conclusions: Hypoglycemia, compared to glycemic variability, is more strongly associated with adverse outcomes in hospitalized, non-critically ill patients. © 2014 Elsevier Ireland Ltd.