Publication: Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878
Issued Date
2002-11-01
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ISSN
00320943
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2-s2.0-18744369890
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.68, No.11 (2002), 1017-1019
Suggested Citation
Pattama Pittayakhajonwut, Man Theerasilp, Palangpon Kongsaeree, Amporn Rungrod, Morakot Tanticharoen, Yodhathai Thebtaranonth Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878. Planta Medica. Vol.68, No.11 (2002), 1017-1019. doi:10.1055/s-2002-35653 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19967
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Title
Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878
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Abstract
A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively.