Publication: Paracetamol disposition in Thai patients during and after treatment of falciparum malaria
Issued Date
1995-03-01
Resource Type
ISSN
14321041
00316970
00316970
Other identifier(s)
2-s2.0-0028920215
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Clinical Pharmacology. Vol.48, No.1 (1995), 65-69
Suggested Citation
S. Ismail, D. J. Back, G. Edwards, K. Na Bangchang, J. Karbwang Paracetamol disposition in Thai patients during and after treatment of falciparum malaria. European Journal of Clinical Pharmacology. Vol.48, No.1 (1995), 65-69. doi:10.1007/BF00202175 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17440
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Paracetamol disposition in Thai patients during and after treatment of falciparum malaria
Author(s)
Other Contributor(s)
Abstract
Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria. We have measured plasma concentrations and the urinary excretion of paracetamol and its phase II metabolites in eight Thai patients during uncomplicated falciparum malaria and in convalescence, following a 1000 mg single oral dose. The apparent oral clearance (Malaria, 3.6; Convalescence, 3.9; ml·min-1·kg-1), the elimination half-life (Malaria, 3.8; Convalescence, 3.7 h) and apparent volume of distribution (Malaria, 1.2; Convalescence, 1.2; l·kg-1) of paracetamol were similar during malaria and convalescence. In addition, the urinary excretion of paracetamol and its major phase II metabolites and their formation clearances from paracetamol were not significantly different between the two study phases. These data show that clinical malaria infection has no effect on the conjugation of paracetamol in man. © 1995 Springer-Verlag.