Publication: Cyclosporine in chronic inflammatory demyelinating polyradiculoneuropathy
Issued Date
2005-11-01
Resource Type
ISSN
08878994
Other identifier(s)
2-s2.0-27144502019
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pediatric Neurology. Vol.33, No.5 (2005), 368-372
Suggested Citation
Anannit Visudtibhan, Surang Chiemchanya, Pongsakdi Visudhiphan Cyclosporine in chronic inflammatory demyelinating polyradiculoneuropathy. Pediatric Neurology. Vol.33, No.5 (2005), 368-372. doi:10.1016/j.pediatrneurol.2005.05.015 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16761
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Cyclosporine in chronic inflammatory demyelinating polyradiculoneuropathy
Other Contributor(s)
Abstract
This study demonstrates the efficacy of cyclosporine included in a regimen for the treatment of steroid-resistant chronic inflammatory demyelinating polyradiculoneuropathy in two children. Clinical response was characterized by either decreased frequency of recurrent weakness or normalized motor function. Nerve conduction studies and monitoring of cyclosporine levels were included in the serial follow-up evaluations, and their results were used in formulating a treatment plan. One of the two children, who had been monitored for 56 months since the onset of the disease, was able to maintain normal muscle strength without recurrent weakness for 39 months, with 5 mg/kg daily of cyclosporine. The other child, who had been taking prednisolone 0.3 mg/kg daily and cyclosporine 5 mg/kg daily, regained ambulation without support while demonstrating a reduction of recurrent weakness. None had adverse effects caused by cyclosporine therapy. We conclude that cyclosporine is an effective drug in the treatment of children with steroid-resistant chronic inflammatory demyelinating polyradiculoneuropathy. © 2005 by Elsevier Inc. All rights reserved.