Publication:
Enhancement of den-induced hepatocellular nodule development by opisthorchis viverrini infection in syrian golden hamsters

Issued Date

1987-09-01

Resource Type

Article

ISSN

01433334

DOI

10.1093/carcin/8.9.1351

Other identifier(s)

2-s2.0-0023228260

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Carcinogenesis. Vol.8, No.9 (1987), 1351-1353

Suggested Citation

Witaya Thamavit, Maya Ngamying, Vijitr Boonpucknavig, Somnate Boonpucknavig, Malcolm A. Moore Enhancement of den-induced hepatocellular nodule development by opisthorchis viverrini infection in syrian golden hamsters. Carcinogenesis. Vol.8, No.9 (1987), 1351-1353. doi:10.1093/carcin/8.9.1351 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15311

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Title

Enhancement of den-induced hepatocellular nodule development by opisthorchis viverrini infection in syrian golden hamsters

Author(s)

Witaya Thamavit
 Maya Ngamying
 Vijitr Boonpucknavig
 Somnate Boonpucknavig
 Malcolm A. Moore

Other Contributor(s)

Mahidol University
 University of New South Wales (UNSW) Australia

Abstract

The influence of Opisthorchis viverrini liver fluke infection on development of diethylnitrosamine (DEN)-induced hepatocellular nodules was investigated in Syrian golden hamsters. Infection with 60 metacercariae, 4 weeks prior to administration of DEN for 12 weeks in the drinking water at dose levels of 10, 20 and 40 p.p.m., resulted in a significantly increased yield of nodular lesions as compared with the group receiving carcinogen treatment alone. The results indicate an importance for parasite-associated liver injury and compensatory regeneration in hepatocarcinogenesis and suggest a possible role for Opisthorchis infestation in the generation of hepatocellular tumours in man. © 1987 IRL Press Limited.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/15311

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Scopus 1969-1990