Publication: Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria
Accepted Date
2008-10-21
Issued Date
2008-10-21
Copyright Date
2008
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Language
eng
ISSN
1475-2875 (electronic)
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Mahidol University
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BioMed Central
Bibliographic Citation
Susomboon P, Iwagami M, Tangpukdee N, Krusood S, Looareesuwan S, Kano S. Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria. Malar J. 2008 Oct 21;7:212.
Suggested Citation
Pannapa Susomboon, พรรณนภา สุสมบูรณ์, Iwagami, Moritoshi, Noppadon Tangpukdee, นพดล ตั้งภักดี, Srivicha Krusood, ศรีวิชา ครุฑสูตร, Sornchai Looareesuwan, ศรชัย หลูอารีย์สุวรรณ, Kano, Shigeyuki Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria. Susomboon P, Iwagami M, Tangpukdee N, Krusood S, Looareesuwan S, Kano S. Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria. Malar J. 2008 Oct 21;7:212.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/712
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Title
Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria
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Abstract
BACKGROUND: There have been many reports on the population genetic structures of
Plasmodium falciparum from different endemic regions, but few studies have
examined the characteristics of isolates from patients with different clinical
outcomes. The population genetic structures of P. falciparum isolates from
patients with either severe or uncomplicated malaria were examined.
METHODS: Twelve microsatellite DNA loci from P. falciparum were used to assess
the population genetic structures of 50 isolates (i.e., 25 isolates from patients
with severe malaria and 25 from patients with uncomplicated malaria) collected in
the Thai-Myanmar border area between 2002 and 2005.
RESULTS: Genetic diversity and effective population sizes were greater in the
uncomplicated malaria group than in the severe malaria group. Evidence of genetic
bottlenecks was not observed in either group. Strong linkage disequilibrium was
observed in the uncomplicated malaria group. The groups demonstrated significant
genetic differentiation (P < 0.05), and allele frequencies for 3 of the 12
microsatellite loci differed significantly between the two groups.
CONCLUSION: These findings suggest that the genetic structure of P. falciparum
populations in patients with severe malaria differs from that in patients with
uncomplicated malaria. The microsatellite loci used in this study were presumably
unrelated to antigenic features of the parasites, but, these findings suggest
that some loci may influence the clinical outcome of malaria.