Publication: Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate)
Issued Date
2010-08-01
Resource Type
ISSN
15507041
15507033
15507033
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2-s2.0-79953012455
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Biomedical Nanotechnology. Vol.6, No.4 (2010), 385-390
Suggested Citation
Saovaree Tanpantree, Pakorn Opaprakasit, Duangporn Polpanich, Srung Smanmoo, Pramuan Tangboriboonrat Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate). Journal of Biomedical Nanotechnology. Vol.6, No.4 (2010), 385-390. doi:10.1166/jbn.2010.1134 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28894
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Title
Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate)
Abstract
Poly(methyl acrylate) (PMA) of various weight average molecular weights (M̄w) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the M̄w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell. Copyright © 2010 American Scientific Publishers. All rights reserved.