Publication:
Heritability of the human infectious reservoir of malaria parasites

Issued Date

2010-08-12

Resource Type

Article

ISSN

19326203

DOI

10.1371/journal.pone.0011358

Other identifier(s)

2-s2.0-77956209235

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

PLoS ONE. Vol.5, No.6 (2010)

Suggested Citation

Yaye Ramatoulaye Lawaly, Anavaj kuntabhai, Laurence Marrama, Lassana Konate, Waraphon Phimpraphi, Cheikh Sokhna, Adama Tall, Fatoumata Diène Sarr, Chayanon Peerapittayamongkol, Chalisa Louicharoen, Bradley S. Schneider, Anaïs Levescot, Arthur Talman, Isabelle Casademont, Didier Menard, Jean François Trape, Christophe Rogier, Jaranit Kaewkunwal, Thanyachai Sura, Issarang Nuchprayoon, Frederic Ariey, Laurence Baril, Pratap Singhasivanon, Odile Mercereau-Puijalon, Rick Paul Heritability of the human infectious reservoir of malaria parasites. PLoS ONE. Vol.5, No.6 (2010). doi:10.1371/journal.pone.0011358 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28471

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Title

Heritability of the human infectious reservoir of malaria parasites

Author(s)

Yaye Ramatoulaye Lawaly
 Anavaj kuntabhai
 Laurence Marrama
 Lassana Konate
 Waraphon Phimpraphi
 Cheikh Sokhna
 Adama Tall
 Fatoumata Diène Sarr
 Chayanon Peerapittayamongkol
 Chalisa Louicharoen
 Bradley S. Schneider
 Anaïs Levescot
 Arthur Talman
 Isabelle Casademont
 Didier Menard
 Jean François Trape
 Christophe Rogier
 Jaranit Kaewkunwal
 Thanyachai Sura
 Issarang Nuchprayoon
 Frederic Ariey
 Laurence Baril
 Pratap Singhasivanon
 Odile Mercereau-Puijalon
 Rick Paul

Other Contributor(s)

Institut Pasteur de Dakar
 Institut Pasteur, Paris
 Universite Cheikh Anta Diop
 Mahidol University
 Institut de Recherche pour le Developpement Dakar
 Institut Pasteur du Cambodge
 IMTSSA Institut de Medecine Tropicale du Service de Sante des Armees
 Chulalongkorn University
 CNRS Centre National de la Recherche Scientifique

Abstract

Background: Studies on human genetic factors associated with malaria have hitherto concentrated on their role in susceptibility to and protection from disease. In contrast, virtually no attention has been paid to the role of human genetics in eliciting the production of parasite transmission stages, the gametocytes, and thus enhancing the spread of disease. Methods and Findings: We analysed four longitudinal family-based cohort studies from Senegal and Thailand followed for 2-8 years and evaluated the relative impact of the human genetic and non-genetic factors on gametocyte production in infections of Plasmodium falciparum or P. vivax. Prevalence and density of gametocyte carriage were evaluated in asymptomatic and symptomatic infections by examination of Giemsa-stained blood smears and/or RT-PCR (for falciparum in one site). A significant human genetic contribution was found to be associated with gametocyte prevalence in asymptomatic P. falciparum infections. By contrast, there was no heritability associated with the production of gametocytes for P. falciparum or P. vivax symptomatic infections. Sickle cell mutation, HbS, was associated with increased gametocyte prevalence but its contribution was small. Conclusions: The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics. Prospective epidemiological studies will provide an opportunity to generate novel and perhaps more epidemiologically pertinent gametocyte data with which similar analyses can be performed and the role of human genetics in parasite transmission ascertained. © Lawaly et al.

Keyword(s)

Agricultural and Biological Sciences
 Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/28471

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Scopus 2006-2010