Publication: Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: A cross-sectional study
Issued Date
2008-12-01
Resource Type
ISSN
13652265
03000664
03000664
Other identifier(s)
2-s2.0-55949117816
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Endocrinology. Vol.69, No.6 (2008), 885-893
Suggested Citation
Ravi Retnakaran, Byung Soo Youn, Ying Liu, Anthony J G Hanley, Nam Seok Lee, Ji Woo Park, Eun Sun Song, Vivian Vu, Wi Kim, Rungsunn Tungtrongchitr, Peter J. Havel, Michael M. Swarbrick, Collin Shaw, Gary Sweeney Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: A cross-sectional study. Clinical Endocrinology. Vol.69, No.6 (2008), 885-893. doi:10.1111/j.1365-2265.2008.03264.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19459
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Title
Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: A cross-sectional study
Abstract
Objective: Here we use a novel ELISA that is specific for full-length visfatin (PBEF/NAMPT), compare it with the existing C-terminal based assay and use it to investigate associations of visfatin with metabolic parameters. Design, patients and measurements: We established the specificity and effectiveness of the new ELISA and evaluated the associations of full-length visfatin with clinical, anthropometric and metabolic parameters in a cross-sectional study of 129 Thai subjects, consisting of 50 outpatients with type 2 diabetes and 79 healthy volunteers. Results: The new ELISA accurately recovered full-length recombinant visfatin and detected visfatin secreted by primary human and rat adipocytes. We found serum full-length visfatin was significantly higher in subjects with diabetes compared to their nondiabetic peers (median 2.75 vs. 2.22 ng/ml, P = 0.0142). After adjustment for age, gender and traditional metabolic risk factors, adjusted mean visfatin remained significantly higher in the diabetes group (3.80 vs. 2.10 ng/ml, P = 0.0021). On Spearman univariate correlation analysis, visfatin was significantly associated with resistin (r = 0.30, P = 0.0011), but not with any other anthropometric or metabolic variables, including adiponectin multimers. On multiple linear regression analysis, the only covariates independently associated with visfatin were diabetes (t = 3.11, P = 0.0024) and log resistin (t = 2.68, P = 0.0086). Conclusions: Circulating visfatin is independently associated with diabetes and resistin concentration, but is not related to adiponectin multimers or other metabolic covariates. These data are suggestive of a potential role of visfatin in subclinical inflammatory states. © 2008 The Authors.