Publication: Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study
Issued Date
2019-11-01
Resource Type
ISSN
15524604
00912700
00912700
Other identifier(s)
2-s2.0-85067069116
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Pharmacology. Vol.59, No.11 (2019), 1519-1526
Suggested Citation
Lihong Du, Larissa A. Wenning, Brendan Carvalho, Lelia Duley, Kathleen F. Brookfield, Han Witjes, Rik de Greef, Pisake Lumbiganon, Vitaya Titapant, Kiattisak Kongwattanakul, Qian Long, Ussanee S. Sangkomkamhang, Ahmet M. Gülmezoglu, Olufemi T. Oladapo Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study. Journal of Clinical Pharmacology. Vol.59, No.11 (2019), 1519-1526. doi:10.1002/jcph.1448 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51347
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Title
Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study
Other Contributor(s)
Duke Kunshan University
Stanford University School of Medicine
Organisation Mondiale de la Santé
Faculty of Medicine, Khon Kaen University
Oregon Health and Science University
University of Nottingham
Khon Kaen Regional Hospital
Faculty of Medicine, Siriraj Hospital, Mahidol University
Merck & Co., Inc.
Certara Strategic Consulting
Stanford University School of Medicine
Organisation Mondiale de la Santé
Faculty of Medicine, Khon Kaen University
Oregon Health and Science University
University of Nottingham
Khon Kaen Regional Hospital
Faculty of Medicine, Siriraj Hospital, Mahidol University
Merck & Co., Inc.
Certara Strategic Consulting
Abstract
© 2019 Meck Sharp & Dohme Corp. The Journal of Clinical Pharmacology published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology Magnesium sulfate is the anticonvulsant of choice for eclampsia prophylaxis and treatment; however, the recommended dosing regimens are costly and cumbersome and can be administered only by skilled health professionals. The objectives of this study were to develop a robust exposure-response model for the relationship between serum magnesium exposure and eclampsia using data from large studies of women with preeclampsia who received magnesium sulfate, and to predict eclampsia probabilities for standard and alternative (shorter treatment duration and/or fewer intramuscular injections) regimens. Exposure-response modeling and simulation were applied to existing data. A total of 10 280 women with preeclampsia who received magnesium sulfate or placebo were evaluated. An existing population pharmacokinetic model was used to estimate individual serum magnesium exposure. Logistic regression was applied to quantify the serum magnesium area under the curve-eclampsia rate relationship. Our exposure-response model-estimated eclampsia rates were comparable to observed rates. Several alternative regimens predicted magnesium peak concentration < 3.5 mmol/L (empiric safety threshold) and eclampsia rate ≤ 0.7% (observed response threshold), including 4 g intravenously plus 10 g intramuscularly followed by either 8 g intramuscularly every 6 hours × 3 doses or 10 g intramuscularly every 8 hours × 2 doses and 10 g intramuscularly every 8 hours × 3 doses. Several alternative magnesium sulfate regimens with comparable model-predicted efficacy and safety were identified that merit evaluation in confirmatory clinical trials.