Publication:
Early Height and Weight Changes in Children Using Cotrimoxazole Prophylaxis with Antiretroviral Therapy

Issued Date

2016-11-01

Resource Type

Article

ISSN

15376591
10584838

DOI

10.1093/cid/ciw514

Other identifier(s)

2-s2.0-84994504610

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Clinical Infectious Diseases. Vol.63, No.9 (2016), 1236-1244

Suggested Citation

David C. Boettiger, Dina Muktiarti, Nia Kurniati, Khanh H. Truong, Suneeta Saghayam, Penh Sun Ly, Rawiwan Hansudewechakul, Lam Van Nguyen, Viet Chau Do, Tavitiya Sudjaritruk, Pagakrong Lumbiganon, Kulkanya Chokephaibulkit, Torsak Bunupuradah, Nik Khairulddin Nik Yusoff, Dewi Kumara Wati, Kamarul Azahar Mohd Razali, Moy Siew Fong, Revathy A. Nallusamy, Annette H. Sohn, Azar Kariminia Early Height and Weight Changes in Children Using Cotrimoxazole Prophylaxis with Antiretroviral Therapy. Clinical Infectious Diseases. Vol.63, No.9 (2016), 1236-1244. doi:10.1093/cid/ciw514 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41060

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Title

Early Height and Weight Changes in Children Using Cotrimoxazole Prophylaxis with Antiretroviral Therapy

Author(s)

David C. Boettiger
 Dina Muktiarti
 Nia Kurniati
 Khanh H. Truong
 Suneeta Saghayam
 Penh Sun Ly
 Rawiwan Hansudewechakul
 Lam Van Nguyen
 Viet Chau Do
 Tavitiya Sudjaritruk
 Pagakrong Lumbiganon
 Kulkanya Chokephaibulkit
 Torsak Bunupuradah
 Nik Khairulddin Nik Yusoff
 Dewi Kumara Wati
 Kamarul Azahar Mohd Razali
 Moy Siew Fong
 Revathy A. Nallusamy
 Annette H. Sohn
 Azar Kariminia

Other Contributor(s)

University of New South Wales (UNSW) Australia
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Children's Hospital 1
 YR Gaitonde Centre for AIDS Research and Education
 National Center for HIV/AIDS
 Chiangrai Prachanukroh Hospital
 National Hospital of Pediatrics Hanoi
 Children's Hospital 2
 Chiang Mai University
 Khon Kaen University
 Mahidol University
 The HIV Netherlands Australia Thailand Research Collaboration
 Hospital Raja Perempuan Zainab II
 Universitas Udayana
 Kuala Lumpur Hospital
 Hospital Likas
 Penang Hospital
 amfAR - The Foundation for AIDS Research

Abstract

© The Author 2016. Background. The growth benefits of cotrimoxazole during early antiretroviral therapy (ART) are not well characterized. Methods. Individuals enrolled in the Therapeutics Research, Education, and AIDS Training in Asia Pediatric HIV Observational Database were included if they started ART at ages 1 month-14 years and had both height and weight measurements available at ART initiation (baseline). Generalized estimating equations were used to identify factors associated with change in height-for-age z-score (HAZ), follow-up HAZ ≥ -2, change in weight-for-age z-score (WAZ), and follow-up WAZ ≥ -2. Results. A total of 3217 children were eligible for analysis. The adjusted mean change in HAZ among cotrimoxazole and non-cotrimoxazole users did not differ significantly over the first 24 months of ART. In children who were stunted (HAZ < -2) at baseline, cotrimoxazole use was not associated with a follow-up HAZ ≥ -2. The adjusted mean change in WAZ among children with a baseline CD4 percentage (CD4%) >25% became significantly different between cotrimoxazole and non-cotrimoxazole users after 6 months of ART and remained significant after 24 months (overall P <. 01). Similar changes in WAZ were observed in those with a baseline CD4% between 10% and 24% (overall P <. 01). Cotrimoxazole use was not associated with a significant difference in follow-up WAZ in children with a baseline CD4% <10%. In those underweight (WAZ < -2) at baseline, cotrimoxazole use was associated with a follow-up WAZ ≥ -2 (adjusted odds ratio, 1.70 vs not using cotrimoxazole [95% confidence interval, 1.28-2.25], P <. 01). This association was driven by children with a baseline CD4% ≥10%. Conclusions. Cotrimoxazole use is associated with benefits to WAZ but not HAZ during early ART in Asian children.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/41060

Collections

Scopus 2016-2017