Publication: Antiparasitic chaiyaphumines from entomopathogenic xenorhabdus sp. PB61.4
Issued Date
2014-04-25
Resource Type
ISSN
15206025
01633864
01633864
Other identifier(s)
2-s2.0-84899573046
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.77, No.4 (2014), 779-783
Suggested Citation
Florian Grundmann, Marcel Kaiser, Matthias Schiell, Andreas Batzer, Michael Kurz, Aunchalee Thanwisai, Narisara Chantratita, Helge B. Bode Antiparasitic chaiyaphumines from entomopathogenic xenorhabdus sp. PB61.4. Journal of Natural Products. Vol.77, No.4 (2014), 779-783. doi:10.1021/np4007525 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33269
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Title
Antiparasitic chaiyaphumines from entomopathogenic xenorhabdus sp. PB61.4
Abstract
A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfeys analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents. © 2014 The American Chemical Society and American Society of Pharmacognosy.