Publication: Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis
Issued Date
2021-11-01
Resource Type
ISSN
23265205
23265191
23265191
Other identifier(s)
2-s2.0-85116323480
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Mahidol University
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SCOPUS
Bibliographic Citation
Arthritis and Rheumatology. Vol.73, No.11 (2021), 1966-1975
Suggested Citation
Chiara Trincianti, Evert Hendrik Pieter Van Dijkhuizen, Alessandra Alongi, Marta Mazzoni, Joost F. Swart, Irina Nikishina, Pekka Lahdenne, Lidia Rutkowska-Sak, Tadej Avcin, Pierre Quartier, Violeta Panaviene, Yosef Uziel, Chris Pruunsild, Veronika Vargova, Soamarat Vilaiyuk, Pavla Dolezalova, Sarah Ringold, Marco Garrone, Nicolino Ruperto, Angelo Ravelli, Alessandro Consolaro Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis. Arthritis and Rheumatology. Vol.73, No.11 (2021), 1966-1975. doi:10.1002/art.41879 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77202
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Title
Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis
Author(s)
Chiara Trincianti
Evert Hendrik Pieter Van Dijkhuizen
Alessandra Alongi
Marta Mazzoni
Joost F. Swart
Irina Nikishina
Pekka Lahdenne
Lidia Rutkowska-Sak
Tadej Avcin
Pierre Quartier
Violeta Panaviene
Yosef Uziel
Chris Pruunsild
Veronika Vargova
Soamarat Vilaiyuk
Pavla Dolezalova
Sarah Ringold
Marco Garrone
Nicolino Ruperto
Angelo Ravelli
Alessandro Consolaro
Evert Hendrik Pieter Van Dijkhuizen
Alessandra Alongi
Marta Mazzoni
Joost F. Swart
Irina Nikishina
Pekka Lahdenne
Lidia Rutkowska-Sak
Tadej Avcin
Pierre Quartier
Violeta Panaviene
Yosef Uziel
Chris Pruunsild
Veronika Vargova
Soamarat Vilaiyuk
Pavla Dolezalova
Sarah Ringold
Marco Garrone
Nicolino Ruperto
Angelo Ravelli
Alessandro Consolaro
Other Contributor(s)
Ramathibodi Hospital
Seattle Children's Hospital
Université Paris Cité
V.A. Nasonova Research Institute of Rheumatology
University Children's Hospital, Ljubljana
Wilhelmina Kinderziekenhuis
Tartu Ülikooli Kliinikum
Vilniaus Universitetas
Všeobecná Fakultní Nemocnice v Praze
Pavol Jozef Safarik University in Kosice
Università degli Studi di Genova
Helsinki University Hospital
Istituto Giannina Gaslini
Tel Aviv University
National Institute of Geriatrics
Seattle Children's Hospital
Université Paris Cité
V.A. Nasonova Research Institute of Rheumatology
University Children's Hospital, Ljubljana
Wilhelmina Kinderziekenhuis
Tartu Ülikooli Kliinikum
Vilniaus Universitetas
Všeobecná Fakultní Nemocnice v Praze
Pavol Jozef Safarik University in Kosice
Università degli Studi di Genova
Helsinki University Hospital
Istituto Giannina Gaslini
Tel Aviv University
National Institute of Geriatrics
Abstract
Objective: To develop and validate new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to separate the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with oligoarthritis and with rheumatoid factor–negative polyarthritis, based on subjective disease assessment by the treating pediatric rheumatologist. Methods: The cutoffs definition cohort was composed of 1,936 patients included in the multinational Epidemiology, Treatment and Outcome of Childhood Arthritis (EPOCA) study. Using the subjective physician rating as an external criterion, 4 methods were applied to identify the cutoffs: mapping, Youden index, 90% specificity, and maximum agreement. The validation cohort included 4,014 EPOCA patients, patients from 2 randomized trials, and 88 patients from the PharmaChild registry. Cutoff validation was conducted by assessing discriminative and predictive ability. Results: The JADAS10 cutoffs were 1.4, 4, and 13, respectively, for oligoarthritis and 2.7, 6, and 17, respectively, for polyarthritis. The cJADAS10 cutoffs were 1.1, 4, and 12, respectively, for oligoarthritis and 2.5, 5, and 16, respectively, for polyarthritis. The cutoffs discriminated strongly among different levels of pain and morning stiffness, between patients who were and those who were not prescribed a new medication, and between different levels of improvement in clinical trials. Achievement of ID and MiDA according to the new JADAS cutoffs at least twice in the first year of disease predicted better outcome at 2 years. Conclusion: The 2021 JADAS and cJADAS cutoffs revealed good metrologic properties in both definition and validation samples, and are therefore suitable for use in clinical trials and routine practice.
