Publication: Pyranonaphthoquinone and anthraquinone derivatives from Ventilago harmandiana and their potent anti-inflammatory activity
Issued Date
2020-01-01
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ISSN
00319422
Other identifier(s)
2-s2.0-85073677804
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry. Vol.169, (2020)
Suggested Citation
Kanda Panthong, Sakchai Hongthong, Chutima Kuhakarn, Pawinee Piyachaturawat, Kanoknetr Suksen, Ampai Panthong, Natthakarn Chiranthanut, Palangpon Kongsaeree, Samran Prabpai, Narong Nuntasaen, Vichai Reutrakul Pyranonaphthoquinone and anthraquinone derivatives from Ventilago harmandiana and their potent anti-inflammatory activity. Phytochemistry. Vol.169, (2020). doi:10.1016/j.phytochem.2019.112182 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49524
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Title
Pyranonaphthoquinone and anthraquinone derivatives from Ventilago harmandiana and their potent anti-inflammatory activity
Abstract
© 2019 Elsevier Ltd The chemical study on the heartwoods extract of Ventilago harmandiana (Rhamnaceae) resulted in the isolation of ten previously undescribed pyranonaphthoquinones (ventilanones A−J), an undescribed anthraquinone (ventilanone K), together with eight known anthraquinone derivatives. Their structures were elucidated by extensive analysis of their spectroscopic data. The absolute configuration of ventilanone A was established from single crystal X-ray crystallographic analysis of its p-bromobenzenesulfonate ester derivative using Cu Kα radiation. The absolute configurations of the other related compounds were identified by comparison of their ECD data with those of ventilanone A and related known compounds. Cytotoxic and anti-inflammatory activities of some of the isolated compounds were evaluated. Ventilanone A and ventilanone C exhibited moderate cytotoxicity against P-388 cell line. Ventilanone D exhibited significant anti-inflammatory activity while ventilanone A and ventilanone C showed moderate activity.