Publication: Airway remodelling in asthma and novel therapy
1
Issued Date
2013-03-01
Resource Type
ISSN
22288694
0125877X
0125877X
Other identifier(s)
2-s2.0-84873556164
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.31, No.1 (2013), 3-10
Suggested Citation
Wiparat Manuyakorn, Peter H. Howarth, Stephen T. Holgate Airway remodelling in asthma and novel therapy. Asian Pacific Journal of Allergy and Immunology. Vol.31, No.1 (2013), 3-10. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31957
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Title
Airway remodelling in asthma and novel therapy
Other Contributor(s)
Abstract
Asthma is an airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness (BHR) and airflow obstruction. Airway structural changes or airway remodelling consist of epithelial injury, goblet cell hyperplasia, subepithelial layer thickening, airway smooth muscle hyperplasia and angiogenesis. These changes were previously considered as a consequence of chronic airway inflammation. However, several studies have demonstrated that inflammation and remodelling can occur as separate but parallel aspects of the asthmatic process. As such there is increasing evidence for the role of mechanocompressive forces within the asthmatic airway contributing to airway structural changes. Furthermore, it is unclear what is the best treatment to modify remodelling and which component to target. There is also a need to identify asthma phenotype that might specifically respond to novel therapies such as anti-IL5, anti-IL13 and tyrosine kinase inhibitors.