Publication: Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in Vivo
Issued Date
2009-04-22
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ISSN
00218561
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2-s2.0-65349134218
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Agricultural and Food Chemistry. Vol.57, No.8 (2009), 3055-3063
Suggested Citation
Kriengsak Lirdprapamongkol, Jan Peter Kramb, Tuangporn Suthiphongchai, Rudee Surarit, Chantragan Srisomsap, Gerd Dannhardt, Jisnuson Svasti Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in Vivo. Journal of Agricultural and Food Chemistry. Vol.57, No.8 (2009), 3055-3063. doi:10.1021/jf803366f Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27025
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Title
Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in Vivo
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Abstract
Vanillin, a food flavoring agent, has been shown to suppress cancer cell migration and metastasis in a mouse model, but its mechanism of action is unknown. In this report, we have examined the antimetastatic potential of vanillin and its structurally related compounds, vanillic acid, vanillyl alcohol, and apocynin on hepatocyte growth factor (HGF)-induced migration of human lung cancer cells by the Transwell assay. Vanillin and apocynin could inhibit cell migration, and both compounds selectively inhibited Akt phosphorylation of HGF signaling, without affecting phosphorylation of Met and Erk. Vanillin and apocynin could inhibit the enzymatic activity of phosphoinositide 3-kinase (PI3K), as revealed by an in vitro lipid kinase assay, suggesting that inhibition of PI3K activity was a mechanism underlying the inhibitory effect on cancer cell migration, and the presence of an aldehyde or ketone group in the vanillin structure was important for this inhibition. Vanillin and apocynin also inhibited angiogenesis, determined by the chick chorioallantoic membrane assay. © 2009 American Chemical Society.