Publication: Association between inflammatory marker, environmental lead exposure, and glutathione S-transferase gene
Issued Date
2013-03-11
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ISSN
23146141
23146133
23146133
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2-s2.0-84874607136
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Mahidol University
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SCOPUS
Bibliographic Citation
BioMed Research International. Vol.2013, (2013)
Suggested Citation
Jintana Sirivarasai, Winai Wananukul, Sming Kaojarern, Suwannee Chanprasertyothin, Nisakron Thongmung, Wipa Ratanachaiwong, Thanyachai Sura, Piyamit Sritara Association between inflammatory marker, environmental lead exposure, and glutathione S-transferase gene. BioMed Research International. Vol.2013, (2013). doi:10.1155/2013/474963 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31346
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Title
Association between inflammatory marker, environmental lead exposure, and glutathione S-transferase gene
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Abstract
A number of studies suggested that lead is related to the induction of oxidative stress, and alteration of immune response. In addition, modifying these toxic effects varied partly by GST polymorphism. The objectives of this study were to assess the association between the lead-induced alteration in serum hs-CRP, with GSTM1, GSTT1, and GSTP1 Val105Ile genetic variations and the health consequence from environmental lead exposure. The 924 blood samples were analyzed for blood lead, CRP, and genotyping of three genes with real-time PCR. Means of blood lead and serum hs-CRP were 5.45 g/dL and 2.07 mg/L. Both CRP and systolic blood pressure levels were significantly higher for individuals with blood lead in quartile 4 (6.48-24.63 g/dL) compared with those in quartile 1 (1.23-3.47 g/dL, P<0.01). In particular, in men with blood lead >6.47 g/dL the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with wild-type allele was 1.46 (95% CI; 1.05-2.20), 1.32 (95% CI; 1.03-1.69), 1.65 (95% CI; 1.17-2.35), and 1.98 (95% CI; 1.47-2.55), respectively. Our findings suggested that lead exposure is associated with adverse changes in inflammatory marker and SBP. GST polymorphisms are among the genetic determinants related to lead-induced inflammatory response. © 2013 Jintana Sirivarasai et al.