Publication:
Dual Analysis of Loss to Follow-up for Perinatally HIV-Infected Adolescents Receiving Combination Antiretroviral Therapy in Asia

Issued Date

2019-12-15

Resource Type

Article

ISSN

19447884

DOI

10.1097/QAI.0000000000002184

Other identifier(s)

2-s2.0-85074741775

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of acquired immune deficiency syndromes (1999). Vol.82, No.5 (2019), 431-438

Suggested Citation

Adam W. Bartlett, Pagakrong Lumbiganon, Thahira A. Jamal Mohamed, Keswadee Lapphra, Dina Muktiarti, Quy Tuan Du, Rawiwan Hansudewechakul, Penh Sun Ly, Khanh Huu Truong, Lam Van Nguyen, Thanyawee Puthanakit, Tavitiya Sudjaritruk, Kulkanya Chokephaibulkit, Viet Chau Do, Nagalingeswaran Kumarasamy, Nik Khairulddin Nik Yusoff, Nia Kurniati, Moy Siew Fong, Dewi Kumara Wati, Revathy Nallusamy, Annette H. Sohn, Azar Kariminia Dual Analysis of Loss to Follow-up for Perinatally HIV-Infected Adolescents Receiving Combination Antiretroviral Therapy in Asia. Journal of acquired immune deficiency syndromes (1999). Vol.82, No.5 (2019), 431-438. doi:10.1097/QAI.0000000000002184 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51244

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Title

Dual Analysis of Loss to Follow-up for Perinatally HIV-Infected Adolescents Receiving Combination Antiretroviral Therapy in Asia

Author(s)

Adam W. Bartlett
 Pagakrong Lumbiganon
 Thahira A. Jamal Mohamed
 Keswadee Lapphra
 Dina Muktiarti
 Quy Tuan Du
 Rawiwan Hansudewechakul
 Penh Sun Ly
 Khanh Huu Truong
 Lam Van Nguyen
 Thanyawee Puthanakit
 Tavitiya Sudjaritruk
 Kulkanya Chokephaibulkit
 Viet Chau Do
 Nagalingeswaran Kumarasamy
 Nik Khairulddin Nik Yusoff
 Nia Kurniati
 Moy Siew Fong
 Dewi Kumara Wati
 Revathy Nallusamy
 Annette H. Sohn
 Azar Kariminia

Other Contributor(s)

VHS Medical Centre India
 National Hospital of Pediatrics Hanoi
 Universitas Udayana
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Chulalongkorn University
 Kirby Institute
 Faculty of Medicine, Khon Kaen University
 Kuala Lumpur Hospital
 The HIV Netherlands Australia Thailand Research Collaboration
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 Chiang Mai University
 Children's Hospital 2
 National Center for HIV/AIDS
 Children's Hospital 1
 Hospital Raja Perempuan Zainab II
 Foundation for AIDS Research
 Chiangrai Prachanukroh Hospital
 Hospital Likas
 Penang Hospital

Abstract

BACKGROUND: Perinatally HIV-infected adolescents (PHIVA) are an expanding population vulnerable to loss to follow-up (LTFU). Understanding the epidemiology and factors for LTFU is complicated by varying LTFU definitions. SETTING: Asian regional cohort incorporating 16 pediatric HIV services across 6 countries. METHODS: Data from PHIVA (aged 10-19 years) who received combination antiretroviral therapy 2007-2016 were used to analyze LTFU through (1) an International epidemiology Databases to Evaluate AIDS (IeDEA) method that determined LTFU as >90 days late for an estimated next scheduled appointment without returning to care and (2) the absence of patient-level data for >365 days before the last data transfer from clinic sites. Descriptive analyses and competing-risk survival and regression analyses were used to evaluate LTFU epidemiology and associated factors when analyzed using each method. RESULTS: Of 3509 included PHIVA, 275 (7.8%) met IeDEA and 149 (4.3%) met 365-day absence LTFU criteria. Cumulative incidence of LTFU was 19.9% and 11.8% using IeDEA and 365-day absence criteria, respectively. Risk factors for LTFU across both criteria included the following: age at combination antiretroviral therapy initiation <5 years compared with age ≥5 years, rural clinic settings compared with urban clinic settings, and high viral loads compared with undetectable viral loads. Age 10-14 years compared with age 15-19 years was another risk factor identified using 365-day absence criteria but not IeDEA LTFU criteria. CONCLUSIONS: Between 12% and 20% of PHIVA were determined LTFU with treatment fatigue and rural treatment settings consistent risk factors. Better tracking of adolescents is required to provide a definitive understanding of LTFU and optimize evidence-based models of care.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/51244

Collections

Scopus 2019