Publication: Utility of cryptococcal antigen screening and evolution of asymptomatic cryptococcal antigenemia among HIV-infected women starting antiretroviral therapy in Thailand
Issued Date
2014-01-01
Resource Type
ISSN
23259582
23259574
23259574
Other identifier(s)
2-s2.0-84907273904
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the International Association of Providers of AIDS Care. Vol.13, No.5 (2014), 434-437
Suggested Citation
Candice K. Kwan, Wanna Leelawiwat, Poj Intalapaporn, Thanomsak Anekthananon, Boonyos Raengsakulrach, Philip J. Peters, Janet M. McNicholl, Benjamin J. Park, Michelle S. McConnell, Paul J. Weidle Utility of cryptococcal antigen screening and evolution of asymptomatic cryptococcal antigenemia among HIV-infected women starting antiretroviral therapy in Thailand. Journal of the International Association of Providers of AIDS Care. Vol.13, No.5 (2014), 434-437. doi:10.1177/2325957413500533 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34096
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Title
Utility of cryptococcal antigen screening and evolution of asymptomatic cryptococcal antigenemia among HIV-infected women starting antiretroviral therapy in Thailand
Abstract
© The Author(s) 2013. Cryptococcal meningitis (CM) remains a significant HIV-associated opportunistic infection in Southeast Asia and Africa, with a high burden of disease and a high mortality rate despite the availability of antiretroviral therapy (ART). We retrospectively examined the utility of cryptococcal antigen screening to identify risk for CM among 211 Thai women initiating ART. Antigenemia prevalence was 11% (n = 9) among 84 women with a CD4 count <100 cells/mm3. Screening identified all women who later developed CM. Cryptococcal antigen titers decreased over time with ART. Our study confirmed findings from previous studies in Thailand and South Africa and provided novel observational data regarding the course of cryptococcal antigenemia in patients initiating ART and the poor efficacy of low-dose fluconazole prophylaxis in preventing CM among patients with antigenemia.