Publication: Chitosan-magnesium aluminum silicate composite dispersions: Characterization of rheology, flocculate size and zeta potential
Issued Date
2008-03-03
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ISSN
03785173
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2-s2.0-38849101555
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Pharmaceutics. Vol.351, No.1-2 (2008), 227-235
Suggested Citation
Wanwisa Khunawattanakul, Satit Puttipipatkhachorn, Thomas Rades, Thaned Pongjanyakul Chitosan-magnesium aluminum silicate composite dispersions: Characterization of rheology, flocculate size and zeta potential. International Journal of Pharmaceutics. Vol.351, No.1-2 (2008), 227-235. doi:10.1016/j.ijpharm.2007.09.038 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19878
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Title
Chitosan-magnesium aluminum silicate composite dispersions: Characterization of rheology, flocculate size and zeta potential
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Abstract
Composite dispersions of chitosan (CS), a positively charged polymer, and magnesium aluminum silicate (MAS), a negatively charged clay, were prepared and rheology, flocculate size and zeta potential of the CS-MAS dispersions were investigated. High and low molecular weights of CS (HCS and LCS, respectively) were used in this study. Moreover, the effects of heat treatment at 60 °C on the characteristics of the CS-MAS dispersions and the zeta potential of MAS upon addition of CS at different pHs were examined. Incorporation of MAS into CS dispersions caused an increase in viscosity and a shift of CS flow type from Newtonian to pseudoplastic flow with thixotropic properties. Heat treatment brought about a significant decrease in viscosity and hysteresis area of the composite dispersions. Microscopic studies showed that flocculation of MAS occurred after mixing with CS. The size and polydispersity index of the HCS-MAS flocculate were greater than those of the LCS-MAS flocculate. However, a narrower size distribution and the smaller size of the HCS-MAS flocculate were found after heating at 60 °C. Zeta potentials of the CS-MAS flocculates were positive and slightly increased with increasing MAS content. In the zeta potential studies, the negative charge of the MAS could be neutralized by the addition of CS. Increasing the pH and molecular weight of CS resulted in higher CS concentrations required to neutralize the charge of MAS. These findings suggest that the electrostatic interaction between CS and MAS caused a change in flow behavior and flocculation of the composite dispersions, depending on the molecular weight of CS. Heat treatment affected the rheological properties and the flocculate size of the composite dispersions. Moreover, pH of medium and molecular weight of CS influence the zeta potential of MAS. © 2007 Elsevier B.V. All rights reserved.