Publication: Fasciola gigantica: Histology of the digestive tract and the expression of cathepsin L
Issued Date
2010-08-01
Resource Type
ISSN
10902449
00144894
00144894
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2-s2.0-77953027135
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Mahidol University
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SCOPUS
Bibliographic Citation
Experimental Parasitology. Vol.125, No.4 (2010), 371-379
Suggested Citation
Krai Meemon, Witoon Khawsuk, Sompong Sriburee, Ardool Meepool, Manussabhorn Sethadavit, Veerawat Sansri, Chaitip Wanichanon, Prasert Sobhon Fasciola gigantica: Histology of the digestive tract and the expression of cathepsin L. Experimental Parasitology. Vol.125, No.4 (2010), 371-379. doi:10.1016/j.exppara.2010.03.003 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29206
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Title
Fasciola gigantica: Histology of the digestive tract and the expression of cathepsin L
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Abstract
The digestive tract of Fasciola gigantica is composed of the oral sucker, buccal tube, pharynx, esophagus, and caecum. The tegumental-type epithelium lines the first four parts of the digestive tract while the caecal-type epithelium lines the remaining parts from the caecal bifurcation. The caecal-epithelial cells are classified into 3 types according to their staining properties and ultrastructural characteristics, as related to the amount of food contents in the caecal lumen. All caecal-type epithelial cells synthesize and secrete cathepsin L, a major group of enzymes in the digestive tract, as detected by in situ hybridization and immunolocalization. Moreover, the secreted cathepsin L is also adsorbed on the outer surface of the tegument and the glycocalyx coating of the surface of the tegument, whereas the tegumental cells and tegumental syncytium covering the parasite's body and lining the proximal part of the digestive tract exhibit no in situ hybridization signal and immunostaining for cathepsin L. © 2010 Elsevier Inc.