Publication:
Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes

Issued Date

2020-01-01

Resource Type

Article

ISSN

15326535
00099236

DOI

10.1002/cpt.1915

Other identifier(s)

2-s2.0-85088238978

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Clinical Pharmacology and Therapeutics. (2020)

Suggested Citation

Chonlaphat Sukasem, Jirawat Pratoomwun, Patompong Satapornpong, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Pawinee Rerknimitr, Pattamon Lertpichitkul, Apichaya Puangpetch, Nontaya Nakkam, Parinya Konyoung, Usanee Khunarkornsiri, Wareeporn Disphanurat, Chutika Srisuttiyakorn, Oranuch Pattanacheewapull, Sirimas Kanjanawart, Thachanan Kongpan, Pansu Chumworathayi, Niwat Saksit, Jackrapong Bruminhent, Wichittra Tassaneeyakul, Wasun Chantratita, Munir Pirmohamed Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes. Clinical Pharmacology and Therapeutics. (2020). doi:10.1002/cpt.1915 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58341

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Title

Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes

Author(s)

Chonlaphat Sukasem
 Jirawat Pratoomwun
 Patompong Satapornpong
 Jettanong Klaewsongkram
 Ticha Rerkpattanapipat
 Pawinee Rerknimitr
 Pattamon Lertpichitkul
 Apichaya Puangpetch
 Nontaya Nakkam
 Parinya Konyoung
 Usanee Khunarkornsiri
 Wareeporn Disphanurat
 Chutika Srisuttiyakorn
 Oranuch Pattanacheewapull
 Sirimas Kanjanawart
 Thachanan Kongpan
 Pansu Chumworathayi
 Niwat Saksit
 Jackrapong Bruminhent
 Wichittra Tassaneeyakul
 Wasun Chantratita
 Munir Pirmohamed

Other Contributor(s)

Liverpool University Hospitals NHS Foundation Trust
 University of Phayao
 Udon Thani Center Hospital
 Chulalongkorn University
 Rangsit University
 King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
 Khon Kaen University
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Khon Kaen Regional Hospital
 Thammasat University
 Phramongkutklao College of Medicine
 The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group

Abstract

© 2020 The Authors Clinical Pharmacology & Therapeutics © 2020 American Society for Clinical Pharmacology and Therapeutics Co-trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case-control study was conducted to investigate the involvement between genetic variants of human leukocyte antigen (HLA) and CYP2C9 in CTX-induced SCARs, including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) in Thai patients. Thirty cases of CTX-induced SCARs were enrolled and compared with 91 CTX-tolerant controls and 150 people from the general Thai population. Cases comprised 18 SJS/TEN and 12 DRESS patients. This study demonstrated that genetic association of CTX-induced SCARs was phenotype-specific. HLA-B*15:02 and HLA-C*08:01 alleles were significantly associated with CTX-induced SJS/TEN, whereas the HLA-B*13:01 allele was significantly associated with CTX-induced DRESS. In addition, a significant higher frequency of HLA-A*11:01-B*15:02 and HLA-B*13:01-C*03:04 haplotypes were detected in the group of CTX-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and DRESS cases, respectively. Genetic association of CTX-induced SCARs is phenotype-specific. Interestingly, these association was observed only in HIV-infected patients but not in non-HIV-infected patients.

Keyword(s)

Medicine
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/58341

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Scopus 2020