Publication: Susceptibility to hydrogen peroxide of Plasmodium falciparum infecting glucose-6-phosphate dehydrogenase-deficient erythrocytes
Issued Date
1989-01-01
Resource Type
ISSN
14698161
00311820
00311820
Other identifier(s)
2-s2.0-0024447668
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Mahidol University
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SCOPUS
Bibliographic Citation
Parasitology. Vol.99, No.2 (1989), 171-174
Suggested Citation
S. Kamchonwongpaisan, A. Bunyaratvej, W. Wanachiwanawin, Y. Yuthavong Susceptibility to hydrogen peroxide of Plasmodium falciparum infecting glucose-6-phosphate dehydrogenase-deficient erythrocytes. Parasitology. Vol.99, No.2 (1989), 171-174. doi:10.1017/S0031182000058601 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15699
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Title
Susceptibility to hydrogen peroxide of Plasmodium falciparum infecting glucose-6-phosphate dehydrogenase-deficient erythrocytes
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Abstract
The susceptibility to oxidant–mediated killing of Plasmodium falciparum infecting normal and glucose–6–phosphate dehydrogenase (G6PD)–deficient erythrocytes was assessed by exposure to hydrogen peroxide generated by the glucose—glucose oxidase system. The parasites infecting G6PD–deficient erythrocytes had markedly greater susceptibility to hydrogen peroxide under a variety of conditions than those infecting normal erythrocytes. In both cases, the killing effect was mediated mainly through the host cells since treatment of the erythrocytes with hydrogen peroxide did not change their relative susceptibility. The parasites were most susceptible during maturation, especially in G6PD–deficient erythrocytes, although a reduction in parasite invasion was also observed. The role of oxidant–mediated killing in the protection of G6PD–deficient hosts from P. falciparum infection is discussed. © 1989, Cambridge University Press. All rights reserved.