Publication: Testicular enlargement in a pre-pubertal boy with adrenocortical tumour
Issued Date
2018-01-02
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ISSN
20469055
20469047
20469047
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2-s2.0-85010702226
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Mahidol University
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SCOPUS
Bibliographic Citation
Paediatrics and International Child Health. Vol.38, No.1 (2018), 66-68
Suggested Citation
Manassawee Korwutthikulrangsri, Duangkamon Wattanatranon, Sumate Teeraratkul, Piyathida Wijarn, Pat Mahachoklertwattana, Preamrudee Poomthavorn Testicular enlargement in a pre-pubertal boy with adrenocortical tumour. Paediatrics and International Child Health. Vol.38, No.1 (2018), 66-68. doi:10.1080/20469047.2016.1262577 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/47003
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Title
Testicular enlargement in a pre-pubertal boy with adrenocortical tumour
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Abstract
© 2017 Informa UK Limited, trading as Taylor & Francis Group. Adrenocortical tumours are rare in children. Virilisation caused by overproduction of adrenal androgens is the most common presentation. The testes of pre-pubertal boys with this tumour are usually small or of pre-pubertal size. A 4.8-year-old boy with an adrenocortical tumour and symmetrical pubertal-sized testes is reported. The serum testosterone level was 204 nmol/L (<0.7), dehydro-epiandrosterone-sulphate 56.7 μmol/L (<1.5) and luteinising and follicle-stimulating hormones were at suppressed levels. Histology demonstrated a diffusely increased mean tubular diameter of 90 μm (the size in a 12-year-old boy) and hyperplasia of Sertoli cells. There were no Leydig cells in the interstitial area. Prolonged exposure to an extraordinarily high testosterone level could have had stimulating effects on the seminiferous tubules and Sertoli cell growth and thus contributed to testicular enlargement.