Publication: Bone marrow and cord blood stem cell transplantation for thalassemia in Thailand
4
Issued Date
1997-03-01
Resource Type
ISSN
02683369
Other identifier(s)
2-s2.0-0031003083
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Mahidol University
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SCOPUS
Bibliographic Citation
Bone Marrow Transplantation. Vol.19, No.SUPPL. 2 (1997), 54-56
Suggested Citation
S. Issaragrisil, V. Suvatte, S. Visuthisakchai, V. S. Tanphaichitr, D. Chandanayingyong, V. Chongkolwatana, Y. U-pratya, M. Yimyam, C. Mahasandana Bone marrow and cord blood stem cell transplantation for thalassemia in Thailand. Bone Marrow Transplantation. Vol.19, No.SUPPL. 2 (1997), 54-56. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18155
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Title
Bone marrow and cord blood stem cell transplantation for thalassemia in Thailand
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Abstract
Thalassemias and hemoglobinopathies are prevalent in Thailand. Bone marrow transplantation is the only curative therapy for thalassemia. We report 28 transplants in 26 patients with thalassemia. Twenty-one patients underwent bone marrow transplantation after conditioning with busulfan 14 mg/kg and cyclophosphamide 200 mg/kg. The outcome was favorable in those with hepatomegaly and splenomegaly ≤ 2 cm below costal margin. Graft rejection is a problem in the patients who have severe manifestations as determined by enlargement of liver and spleen > 2 cm below costal margin. A higher dose of busulfan 600 mg/m2 was used in seven patients who had severe manifestations with success. Cord blood is an alternative source of stem cells for transplant. Cord blood was collected from HLA-identical unaffected neonates and used for transplant into affected siblings. Five out of 6 pateints who underwent cord blood transplantation are alive and well.