Publication:
Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania

Issued Date

2012-05-28

Resource Type

Article

ISSN

14752875

DOI

10.1186/1475-2875-11-176

Other identifier(s)

2-s2.0-84861366881

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Malaria Journal. Vol.11, (2012)

Suggested Citation

Anna Färnert, Johan Ursing, Thomas Tolfvenstam, Josea Rono, Lillemor Karlsson, Elda Sparrelid, Niklas Lindegårdh Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania. Malaria Journal. Vol.11, (2012). doi:10.1186/1475-2875-11-176 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14318

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Title

Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania

Author(s)

Anna Färnert
 Johan Ursing
 Thomas Tolfvenstam
 Josea Rono
 Lillemor Karlsson
 Elda Sparrelid
 Niklas Lindegårdh

Other Contributor(s)

Karolinska Institutet
 Karolinska University Hospital
 Mahidol University
 Nuffield Department of Clinical Medicine

Abstract

Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment. © 2012 Färnert et al.; licensee BioMed Central Ltd.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/14318

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Scopus 2011-2015