Publication: Can treatment of P. vivax lead to a unexpected appearance of falciparum malaria?
Issued Date
2001-03-01
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ISSN
01251562
Other identifier(s)
2-s2.0-0035292348
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.1 (2001), 57-63
Suggested Citation
Daniel Philippe Mason, Srivicha Krudsood, Polrat Wilairatana, Parnpen Viriyavejakul, Udomsak Silachamroon, Watcharee Chokejindachai, Pratap Singhasivanon, Suvanee Supavej, F. Ellis McKenzie, Sornchai Looareesuwan Can treatment of P. vivax lead to a unexpected appearance of falciparum malaria?. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.1 (2001), 57-63. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26835
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Title
Can treatment of P. vivax lead to a unexpected appearance of falciparum malaria?
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Abstract
Of 994 patients admitted to the Bangkok Hospital for Tropical Diseases for P. vivax malaria, 104 (10.5%) experienced appearance of Plasmodium falciparum following drug treatment for P. vivax. In all patients, P. falciparum parasites were not found by microscopic examination upon admission. The mean time for P. falciparum appearance was 12.6 days after the commencement of chloroquine treatment. Patients experiencing appearance of P. falciparum had significantly lower hematocrit, and greater initial P. vivax parasite counts. We use a mathematical model to explore the consequences of chloroquine treatment of such mixed infections. Both clinical results and features of the model suggest that such "hidden infections" may be quite common, and that the appearance of P. falciparum may be stimulated by treatment of P. vivax.