Publication: The role of vascular endothelial growth factor A polymorphisms in breast cancer
Issued Date
2012-01-01
Resource Type
ISSN
14220067
16616596
16616596
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2-s2.0-84870704754
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences. Vol.13, No.11 (2012), 14845-14864
Suggested Citation
Doonyapat Sa-nguanraksa, Pornchai O-charoenrat The role of vascular endothelial growth factor A polymorphisms in breast cancer. International Journal of Molecular Sciences. Vol.13, No.11 (2012), 14845-14864. doi:10.3390/ijms131114845 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13852
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Title
The role of vascular endothelial growth factor A polymorphisms in breast cancer
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Abstract
Breast cancer is the most common cancer in females and the leading cause of cancer death in women worldwide. Angiogenesis, the formation of new blood vessels, plays an important role in the development and progression of breast cancer. Vascular endothelial growth factor A (VEGFA), the key modulator of angiogenesis, is highly expressed in cancer tissue and correlates with its more aggressive features. Polymorphisms of VEGFA alter the levels of expression and subsequently influence the susceptibility and aggressiveness of breast cancer. Assessment of VEGFA polymorphisms may be used for the identification of patients suitable for anti-VEGFA therapy. © 2012 by the authors; licensee MDPI, Basel, Switzerland.