Publication: The Suppression of Haemoglobin E Synthesis When tIaemoglobin II Disease and Itaemoglobin E Trait occur together
Issued Date
1967
Resource Type
Language
eng
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Mahidol University
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Springer Nature
Bibliographic Citation
Humangenetik. Vol.3, (1967), 312–318
Suggested Citation
Tuchinda, S., Beale, D., Lehmann, H. The Suppression of Haemoglobin E Synthesis When tIaemoglobin II Disease and Itaemoglobin E Trait occur together. Humangenetik. Vol.3, (1967), 312–318. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/52426
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Title
The Suppression of Haemoglobin E Synthesis When tIaemoglobin II Disease and Itaemoglobin E Trait occur together
Author(s)
Abstract
The blood of two infants with Haemoglobin E trait and a form of α-thalassaemia (Haemoglobin H Disease) was examined and it was confirmed that the proportion of Haemoglobin A:E was higher than in uncomplicated Haemoglobin E trait.
Haemoglobin H (β 4A) was added to the haemoglobin solution from a Haemoglobin E trait carrier. This mixture was dissociated into its α2, β 2A and β 2E subunits, and these were then recombined. The proportion of A:E had risen to that found in vivo in Haemoglobin E trait carriers with Haemoglobin H Disease.
It is suggested that competition between βA and βE for α-chains may be an example of the mechanism by which α-thalassaemia ‘interacts’ with β-chain abnormal haemoglobins.