Publication:
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy

Issued Date

2010-02-01

Resource Type

Article

ISSN

15537404
15537390

DOI

10.1371/journal.pgen.1000856

Other identifier(s)

2-s2.0-77649210349

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

PLoS Genetics. Vol.6, No.2 (2010)

Suggested Citation

Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Kirsi Sipilä, Raija Lähdesmäki, Iona Y. Millwood, Marika Kaakinen, Gopalakrishnan Netuveli, David Blane, Pimphen Charoen, Ulla Sovio, Anneli Pouta, Nelson Freimer, Anna Liisa Hartikainen, Jaana Laitinen, Sarianna Vaara, Beate Glaser, Peter Crawford, Nicholas J. Timpson, Susan M. Ring, Guohong Deng, Weihua Zhang, Mark I. McCarthy, Panos Deloukas, Leena Peltonen, Paul Elliott, Lachlan J.M. Coin, George Davey Smith, Marjo Riitta Jarvelin Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genetics. Vol.6, No.2 (2010). doi:10.1371/journal.pgen.1000856 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28540

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Title

Genome-wide association study reveals multiple loci associated with primary tooth development during infancy

Author(s)

Demetris Pillas
 Clive J. Hoggart
 David M. Evans
 Paul F. O'Reilly
 Kirsi Sipilä
 Raija Lähdesmäki
 Iona Y. Millwood
 Marika Kaakinen
 Gopalakrishnan Netuveli
 David Blane
 Pimphen Charoen
 Ulla Sovio
 Anneli Pouta
 Nelson Freimer
 Anna Liisa Hartikainen
 Jaana Laitinen
 Sarianna Vaara
 Beate Glaser
 Peter Crawford
 Nicholas J. Timpson
 Susan M. Ring
 Guohong Deng
 Weihua Zhang
 Mark I. McCarthy
 Panos Deloukas
 Leena Peltonen
 Paul Elliott
 Lachlan J.M. Coin
 George Davey Smith
 Marjo Riitta Jarvelin

Other Contributor(s)

Imperial College London
 International Centre for Life
 UCL Institute of Child Health
 University of Bristol
 Oulun Yliopisto
 Oulu University Hospital
 University of Oxford
 Mahidol University
 National Institutes of Health, Bethesda
 Jane & Terry Semel Institute for Neuroscience & Human Behavior
 University of California, Los Angeles
 Tyoterveyslaitos
 Wellcome Trust Centre for Human Genetics
 Wellcome Trust Sanger Institute
 Institute for Molecular Medicine Finland (FIMM)
 Helsingin Yliopisto
 National Institute for Health and Welfare
 Medical Research Council

Abstract

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5×10-8, and 5 with suggestive association (P<5×10-6). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years. © 2010 Pillas et al.

Keyword(s)

Agricultural and Biological Sciences
 Biochemistry, Genetics and Molecular Biology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/28540

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Scopus 2006-2010