Publication: Fluorescence-guided biopsy in tile diagnosis of an unknown primary cancer in patients with metastatic cervical lymph nodes
Issued Date
1999-01-01
Resource Type
ISSN
00034894
Other identifier(s)
2-s2.0-0032802533
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Mahidol University
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SCOPUS
Bibliographic Citation
Annals of Otology, Rhinology and Laryngology. Vol.108, No.7 I (1999), 700-704
Suggested Citation
Boonchu Kulapaditharom, Vipa Boonkitticharoen, Somyos Kunachak Fluorescence-guided biopsy in tile diagnosis of an unknown primary cancer in patients with metastatic cervical lymph nodes. Annals of Otology, Rhinology and Laryngology. Vol.108, No.7 I (1999), 700-704. doi:10.1177/000348949910800715 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25725
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Title
Fluorescence-guided biopsy in tile diagnosis of an unknown primary cancer in patients with metastatic cervical lymph nodes
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Abstract
This study was conducted to determine the effectiveness of fluorescence- guided biopsy in diagnosis of unknown primary cancers in the head and neck. Thirteen patients with biopsy-proven cervical node metastases were evaluated prospectively with laser-induced fluorescence (LIF) endoscopy in parallel to panendoscopy. Among the 13 positive sites suggested by LIF imaging, 5 were confirmed by histopathology as squamous cell carcinoma, 4 as dysplasia, 2 as inflammation, and 2 as normal. Panendoscopy with random biopsies located 2. The 2 cases of squamous cell carcinomas discovered conventionally were identified by histologic sections from ipsilateral tonsillectomy. In this series, the unknown primary cancers were localized by LIF imaging and conventional means at rates of 38.5% and 15.4%, respectively. The LIF imaging not only aided in revealing a greater proportion of occult primary cancers, but also helped in reducing the number of unnecessary biopsies. Fluorescence- guided biopsy diagnosis provides useful information for therapeutic planning with curative aim or for adequate palliation.