Publication: Clinical case definition and manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome
Issued Date
2009-11-01
Resource Type
ISSN
14735571
02699370
02699370
Other identifier(s)
2-s2.0-72949090167
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Mahidol University
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SCOPUS
Bibliographic Citation
AIDS. Vol.23, No.18 (2009), 2467-2471
Suggested Citation
Weerawat Manosuthi, Hong Van Tieu, Wiroj Mankatitham, Aroon Lueangniyomkul, Jintanat Ananworanich, Anchalee Avihingsanon, Umaporn Siangphoe, Sukonsri Klongugkara, Sirirat Likanonsakul, Unchana Thawornwan, Bussakorn Suntisuklappon, Somnuek Sungkanuparph Clinical case definition and manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS. Vol.23, No.18 (2009), 2467-2471. doi:10.1097/QAD.0b013e32832f7b59 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27639
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Title
Clinical case definition and manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome
Abstract
BACKGROUND: The International Network for the Study of HIV-associated IRIS (INSHI) recently published criteria for tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) diagnosis. The performance of this definition and clinical manifestations of TB-IRIS were studied. METHODS: Antiretroviral therapy-naive HIV/TB Thai patients receiving antituberculous therapy were enrolled during 2006-2007 and prospectively followed through 24 weeks of antiretroviral therapy. Patients were defined as having paradoxical TB-IRIS if they fulfilled the 'study definition' by French 2004 and were confirmed by an external reviewer. All were later compared by the classification according to 'INSHI-2008'. RESULTS: For the 126 patients, median baseline CD4 cell count was 43 cells/μl and HIV-1 RNA was 5.9 log10 1̈ copies/ml. Seventy-three (58%) had extrapulmonary/disseminated TB. Twenty-two (18%) and 21 (17%) fulfilled TB-IRIS criteria according to the study definition and INSHI-2008 definition, respectively. Two (2%) were diagnosed by study definition only and one (1%) by INSHI-2008 definition only. Twenty (16%) were concordantly diagnosed by both definitions and 103 (82%) were consistently negative. Eighteen (82%) had worsening of a preexisting site, whereas four (18%) had TB-IRIS in a new location. Lymph node enlargement (73%) and fever (59%) were common in TB-IRIS. Sensitivity and specificity of INSHI-2008 was 91% (95% confidence interval, 72-98%) and 99% (95% confidence interval, 95-99.8%), respectively. Positive predictive value was 95% and negative predictive value was 98%. By multivariate analysis, factors predicting TB-IRIS were extrapulmonary TB (odds ratio, 8.63) and disseminated TB (odds ratio, 4.17). CONCLUSION: There was high concordance between the INSHI-2008 and French 2004 definition for TB-IRIS diagnosis in HIV/TB patients with relatively high rate of paradoxical TB-IRIS. This suggests that lack of HIV-1 RNA and CD4 cell count monitoring does not impede the ability to diagnose TB-IRIS. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.