Publication: Long-term effectiveness of acetazolamide on permanent weakness in hyperkalemic periodic paralysis
Issued Date
2013-05-01
Resource Type
ISSN
18732364
09608966
09608966
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2-s2.0-84876096599
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Mahidol University
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SCOPUS
Bibliographic Citation
Neuromuscular Disorders. Vol.23, No.5 (2013), 445-449
Suggested Citation
Charungthai Dejthevaporn, Chutima Papsing, Bunyong Phakdeekitcharoen, Suphaneewan Jaovisidha, Suchart Phudhichareonrat, Rawiphan Witoonpanich, Teeratorn Pulkes Long-term effectiveness of acetazolamide on permanent weakness in hyperkalemic periodic paralysis. Neuromuscular Disorders. Vol.23, No.5 (2013), 445-449. doi:10.1016/j.nmd.2013.02.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32369
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Title
Long-term effectiveness of acetazolamide on permanent weakness in hyperkalemic periodic paralysis
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Abstract
Acetazolamide is commonly used as an empirical treatment for inherited periodic paralyses although some patients may develop deleterious effects. We report a 65. year-old man with hyperkalemic periodic paralysis and late-onset permanent weakness in association with the common T704M mutation in α-subunit, skeletal muscle voltage-gated sodium channel gene. He rapidly recovered from weakness after acetazolamide treatment. Magnetic resonance imaging of thighs comparing pre- and post-treatment revealed a significant increase in muscle bulk. The patient has been without any type of weakness for over 6. years. This data show the remarkable benefit of acetazolamide on permanent weakness of hyperkalemic periodic paralysis in association with the T704M mutation. © 2013 Elsevier B.V.