Publication: Vaccination of thai infants with rhesus-human reassortant tetravalent oral rotavirus vaccine
1
Issued Date
1994-01-01
Resource Type
ISSN
15320987
08913668
08913668
Other identifier(s)
2-s2.0-0028275438
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Mahidol University
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SCOPUS
Bibliographic Citation
Pediatric Infectious Disease Journal. Vol.13, No.7 (1994), 590-596
Suggested Citation
Sriluck Simasathien, Sricharoen Migasena, Rudiwilai Samakoses, Punnee Pitisuttitham, Preyapan Sangaroon, Chanchai Aree, Ruth Bishop, Helen Bugg, Bruce L. Davidson, Timo Vesikari Vaccination of thai infants with rhesus-human reassortant tetravalent oral rotavirus vaccine. Pediatric Infectious Disease Journal. Vol.13, No.7 (1994), 590-596. doi:10.1097/00006454-199407000-00002 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9847
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Title
Vaccination of thai infants with rhesus-human reassortant tetravalent oral rotavirus vaccine
Abstract
In a randomized double blind placebo-controlled study, the rhesus-human reassortant tet- travalent oral rotavirus vaccine (dose 4 × 10 4 plaque-forming units) was evaluated in Thai infants immunized at ages 2, 4 and 6 months. To investigate dose responses and to compare vaccine-induced and naturally acquired rotavirus immunity in the study population blood specimens were collected before and 1 month after each vaccination and at 12 months of age. No adverse reactions attributable to the vaccine were detected in the vaccinees. Sixty-three of 94 (67%) vaccine recipients showed a seroconversion in rotavirus IgA enzyme-linked immunosorbent assay antibodies after one or more doses, whereas only 15 of 93 (16%) placebo- vaccinated control children showed an IgA enzyme-linked immunosorbent assay antibody response, suggestive of natural rotavirus infection, between 2 and 7 months of age. By measuring rhesus rotavirus-neutralizing antibodies a seroconversion was detected in 49% of the vaccinees and 14% of the controls between 2 and 7 months of age. The geometric mean titers of neutralizing antibodies to human rotavirus serotypes 1, 2, 3 and 4 after the completion of vaccinations and at 12 months of age were higher in the vaccinees than in the controls. It is concluded that, even though maternally acquired rotavirus antibodies are commonly present, the rhesus-humanreassortant tetravalent vaccine is immunogenic in many Thai infants ages 2 to 6 months. The immunogenicity of this vaccine is enhanced by multiple doses. © 1994 by Williams & Wilkins.