Publication: Treatment outcome and persistence of repigmentation from narrow-band ultraviolet B phototherapy in vitiligo
Issued Date
2018-01-01
ISSN
14711753
09546634
09546634
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2-s2.0-85058069366
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Dermatological Treatment. (2018)
Suggested Citation
Narumol Silpa-Archa, Puncharas Weerasubpong, Natchaya Junsuwan, Punyanut Yothachai, Orawan Supapueng, Chanisada Wongpraparut Treatment outcome and persistence of repigmentation from narrow-band ultraviolet B phototherapy in vitiligo. Journal of Dermatological Treatment. (2018). doi:10.1080/09546634.2018.1544409 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47049
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Title
Treatment outcome and persistence of repigmentation from narrow-band ultraviolet B phototherapy in vitiligo
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Abstract
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Background: Narrow-band ultraviolet B (NB-UVB) phototherapy is a mainstay treatment in vitiligo. However, data relative to repigmentation outcome, prognostic factors, and duration of repigmentation are limited. Objectives: To investigate the quantitative repigmentation outcome of NB-UVB phototherapy in vitiligo, the factors associated with favorable prognosis after NB-UVB, and the duration of repigmentation after NB-UVB discontinuation. Materials and methods: Medical records of vitiligo patients who underwent NB-UVB phototherapy at Department of Dermatology, Siriraj Hospital during 2012 to 2016 were retrospectively reviewed. Repigmentation was assessed using Vitiligo Area Scoring Index (VASI) score. Results: Fifty-eight patients were included. All patients received NB-UVB phototherapy twice to three times weekly for a median duration of 12 months. Forty-two patients had nonsegmental vitiligo (NSV), and 16 had segmental vitiligo (SV). NSV and SV demonstrated overall improvement in VASI score of –50.0%±31.0% and −40.0%±28.3%, respectively. Factors predictive of good outcome included type of vitiligo, lesion location, disease duration before NB-UVB, and duration and total number of NB-UVB treatments. Persistence of repigmentation was observed in approximately 80% of cases at one year after discontinuation of NB-UVB. Conclusion: NB-UVB phototherapy is an effective treatment for vitiligo, especially NSV. Repigmentation persisted in 80% of patients at 1 year after cessation of phototherapy.