Publication: Rapid resolution of retinoschisis with acetazolamide
Issued Date
2015-08-24
Resource Type
ISSN
15732622
00124486
00124486
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2-s2.0-84937974134
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Mahidol University
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SCOPUS
Bibliographic Citation
Documenta Ophthalmologica. Vol.131, No.1 (2015), 63-70
Suggested Citation
Lijuan Zhang, Roberto Reyes, Winston Lee, Ching Lung Chen, Lawrence Chan, Tharikarn Sujirakul, Stanley Chang, Stephen H. Tsang Rapid resolution of retinoschisis with acetazolamide. Documenta Ophthalmologica. Vol.131, No.1 (2015), 63-70. doi:10.1007/s10633-015-9496-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36345
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Title
Rapid resolution of retinoschisis with acetazolamide
Abstract
© 2015, Springer-Verlag Berlin Heidelberg. Purpose: To report the results of an acetazolamide (Diamox®) treatment regimen in a genetically confirmed case of X-linked juvenile retinoschisis (XLRS). Methods: A patient with XLRS was prescribed acetazolamide (Diamox®) at a dose of 500 mg/day, then discontinued the treatment due to non-compliance for 4 days, and finally resumed the course of treatment. Best-corrected visual acuity, retinal structure, and function were monitored with autofluorescence, spectral domain-optical coherence tomography (SD-OCT), adaptive optics scanning laser ophthalmoscopy (AOSLO), and full-field electroretinogram (ERG). Full-field ERG was performed using DTL recording electrodes and Ganzfeld stimulation according to ISCEV standards. Results: Serial monitoring of the cysts by SD-OCT revealed a strong association between the effects of acetazolamide administration and the size of the schisis. A reduction in foveal cyst size was significant in as rapid as 6 days after acetazolamide initiation. AOSLO data revealed that the resolution of cone cell images improves as the foveal schisis decreases in size. Conclusions: Efficacy of acetazolamide in patients with XLRS can be apparent in as rapid as a week of therapy. AOSLO can be a good method to evaluate the cone cells after acetazolamide treatment in the early stages of XLRS.