Publication: An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)
Issued Date
2006-08-01
Resource Type
ISSN
13653156
13602276
13602276
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2-s2.0-33746456474
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Mahidol University
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SCOPUS
Bibliographic Citation
Tropical Medicine and International Health. Vol.11, No.8 (2006), 1157-1165
Suggested Citation
M. Mayxay, V. Thongpraseuth, M. Khanthavong, N. Lindegårdh, M. Barends, S. Keola, T. Pongvongsa, S. Phompida, R. Phetsouvanh, K. Stepniewska, N. J. White, P. N. Newton An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos). Tropical Medicine and International Health. Vol.11, No.8 (2006), 1157-1165. doi:10.1111/j.1365-3156.2006.01671.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23317
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Title
An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)
Abstract
OBJECTIVE: To determine the efficacy and safety of oral dihydroartemisinin-piperaquine (DP, Artekin™) in the treatment of uncomplicated Plasmodium falciparum malaria in southern Laos. METHODS: An open, randomized clinical trial of oral artesunate-mefloquine (AM) vs. DP in 220 patients with acute uncomplicated falciparum malaria in Savannakhet Province, Laos. RESULTS: The 42-day cure rates (95% CI), as determined by survival analysis and adjusted for reinfection, were excellent and similar for the two groups [99 (94-100)% and 100 (100-100)% for AM and DP, respectively]. The median (range) fever and parasite clearance times for the AM and DP groups were also similar [20 (4-63) h and 2 (1-4) days vs. 20 (7-57) and 2 (1-4) days, logrank P = 0.4 and 0.17, respectively]. There were more patients with at least one potential side effect following treatment in the AM group when compared with the DP group [64/110 (58%) vs. 48/110 (44%), respectively, P = 0.031]. CONCLUSION: Dihydroartemisinin-piperaquine did not have superior efficacy to AM for the treatment of uncomplicated falciparum malaria in Laos but was associated with fewer adverse effects. © 2006 Blackwell Publishing Ltd.