Publication: Molecular basis of human cerebral malaria development
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Issued Date
2016
Resource Type
Language
eng
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Tropical Medicine and Health. Vol.44, (2016), 33
Suggested Citation
Saw Thu Wah, Hathairad Hananantachai, Usanee Kerdpin, Chotiros Plabplueng, Virapong Prachayasittikul, Pornlada Nuchnoi Molecular basis of human cerebral malaria development. Tropical Medicine and Health. Vol.44, (2016), 33. doi:10.1186/s41182-016-0033-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/2761
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Title
Molecular basis of human cerebral malaria development
Abstract
Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying complex molecular basis of cerebral malaria is important for the design of strategy for cerebral malaria treatment and control.