Publication: Single dose of SA 14-14-2 vaccine provides long-term protection against Japanese encephalitis: A case-control study in Nepalese children 5 years after immunization
Issued Date
2007-06-28
Resource Type
ISSN
0264410X
Other identifier(s)
2-s2.0-34250028171
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Mahidol University
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SCOPUS
Bibliographic Citation
Vaccine. Vol.25, No.27 (2007), 5041-5045
Suggested Citation
J. B. Tandan, Heechoul Ohrr, Young Mo Sohn, Sutee Yoksan, Min Ji, Chung Mo Nam, Scott B. Halstead Single dose of SA 14-14-2 vaccine provides long-term protection against Japanese encephalitis: A case-control study in Nepalese children 5 years after immunization. Vaccine. Vol.25, No.27 (2007), 5041-5045. doi:10.1016/j.vaccine.2007.04.052 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24536
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Title
Single dose of SA 14-14-2 vaccine provides long-term protection against Japanese encephalitis: A case-control study in Nepalese children 5 years after immunization
Abstract
In July 1999, a single dose of live-attenuated SA 14-14-2 Japanese encephalitis (JE) vaccine was administered to children living in the Bardiya, Banke and Kailali districts of Nepal. In 2004, the original vaccinated population experienced a fifth seasonal exposure to JE. We performed a case-control study comparing the prevalence of the administration of vaccine in patients with JE hospitalized in the Bardiya and Bheri Zonal hospitals and in age-sex matched controls resident in the Bardiya district. Among the 219 village controls, 114 had been vaccinated (52.1%) while only one of 20 JE cases had received live-attenuated JE vaccine. Five years after administration of a single dose, SA 14-14-2 provided a protective efficacy of 96.2% (CI 73.1-99.9%). © 2007 Elsevier Ltd. All rights reserved.