Publication: Update in pathophysiology and histopathology of focal segmental glomerulosclerosis
Issued Date
2006-08-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-33846029152
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.89, No.SUPPL. 2 (2006)
Suggested Citation
Talerngsak Kanjanabuch, Songkiat Lewsuwan, Chagriya Kitiyakara, Boonyarit Cheunsuchon, Somchai Eiam-Ong Update in pathophysiology and histopathology of focal segmental glomerulosclerosis. Journal of the Medical Association of Thailand. Vol.89, No.SUPPL. 2 (2006). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23659
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Title
Update in pathophysiology and histopathology of focal segmental glomerulosclerosis
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Abstract
Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome in an adult worldwide. The prevalence of FSGS is estimated as being 20-30% in adults over the age of 15 years and slightly higher (30-35%) in the elderly (age > 60 years). The diagnosis solely relies on pathologic findings, which sclerosis involves some, but not all glomeruli (focal), and sclerosis affects a portion, but not the entire, glomerular tuft (segmental). The pathogenesis remains inconclusive but podocyte injury has been postulated. Even though steroid is the mainstay treatment, only 20-40% of patients are complete respond.