Publication:
A stereoselective approach to bioactive secolignans: Synthesis of peperomin C and its analogues

Issued Date

2014-10-14

Resource Type

Article

ISSN

14645416
00404020

DOI

10.1016/j.tet.2014.07.101

Other identifier(s)

2-s2.0-84907059382

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Tetrahedron. Vol.70, No.41 (2014), 7577-7583

Suggested Citation

Darunee Soorukram, Jaray Panmuang, Patoomratana Tuchinda, Chutima Kuhakarn, Vichai Reutrakul, Manat Pohmakotr A stereoselective approach to bioactive secolignans: Synthesis of peperomin C and its analogues. Tetrahedron. Vol.70, No.41 (2014), 7577-7583. doi:10.1016/j.tet.2014.07.101 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33217

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Title

A stereoselective approach to bioactive secolignans: Synthesis of peperomin C and its analogues

Author(s)

Darunee Soorukram
 Jaray Panmuang
 Patoomratana Tuchinda
 Chutima Kuhakarn
 Vichai Reutrakul
 Manat Pohmakotr

Other Contributor(s)

Mahidol University

Abstract

© 2014 Elsevier Ltd. All rights reserved. A stereoselective approach to secolignans is described. The key synthetic strategy involves an asymmetric aldol reaction to control the creation of the stereogenic center at the β-carbon of the target secolignans. In the present work, peperomin C and its analogues, i.e., 2,6-didehydropeperomin C and 2-epi-peperomin C were successfully synthesized in good yields with high stereoselectivities.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/33217

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