Publication: Adult height, body mass index and time of menarche of girls with idiopathic central precocious puberty after gonadotropin-releasing hormone analogue treatment
Issued Date
2011-08-01
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ISSN
14730766
09513590
09513590
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2-s2.0-79959931994
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Mahidol University
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SCOPUS
Bibliographic Citation
Gynecological Endocrinology. Vol.27, No.8 (2011), 524-528
Suggested Citation
Preamrudee Poomthavorn, Ratchadaporn Suphasit, Pat Mahachoklertwattana Adult height, body mass index and time of menarche of girls with idiopathic central precocious puberty after gonadotropin-releasing hormone analogue treatment. Gynecological Endocrinology. Vol.27, No.8 (2011), 524-528. doi:10.3109/09513590.2010.507289 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11496
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Title
Adult height, body mass index and time of menarche of girls with idiopathic central precocious puberty after gonadotropin-releasing hormone analogue treatment
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Abstract
Background.?Long-term outcome data of central precocious puberty (CPP) girls treated with gonadotropin-releasing hormone analogue (GnRHa) are conflicting. Aim.?To assess long-term outcome of girls with idiopathic CPP (iCPP) treated with GnRHa Methods.?We compared adult height (AH), body mass index (BMI) and time of menarche in GnRHa-treated (n = 47) and untreated (n = 11) girls with iCPP. Results.?There were no differences in age, bone age, height, weight and BMI z-scores, predicted adult height (PAH) at the time of diagnosis and target height between the two groups. Mean (SD) age of GnRHa-treated girls was 8.5 (1.0) years at the start of treatment. Mean (SD) AH of the treated group was greater [158.6 (5.2) vs. 154.8 (5.6) cm], p < 0.05. AH gain over pre-treatment PAH in the treated group was 4.7 cm. BMI z-score of treated girls was 1.26 (0.95) before the treatment initiated and returned to normal [0.16 (1.0)] at the time of AH reached. Menstruation occurred at 0.9 (0.5) years following GnRHa discontinuation with regular pattern. Conclusions.?Long-term GnRHa therapy has a modest beneficial effect on adult height gain in girls with iCPP. No detrimental effects on increasing BMI and hypothalamicpituitarygonadal axis reactivation are demonstrated. © 2010 Informa UK, Ltd.