Publication: Red cell deformability, splenic function and anaemia in thalassaemia
1
Issued Date
1999-05-27
Resource Type
ISSN
00071048
Other identifier(s)
2-s2.0-0032958390
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Mahidol University
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SCOPUS
Bibliographic Citation
British Journal of Haematology. Vol.105, No.2 (1999), 505-508
Suggested Citation
A. M. Dondorp, K. T. Chotivanich, S. Fucharoen, K. Silamut, J. Vreeken, P. A. Kager, N. J. White Red cell deformability, splenic function and anaemia in thalassaemia. British Journal of Haematology. Vol.105, No.2 (1999), 505-508. doi:10.1111/j.1365-2141.1999.01367.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25646
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Title
Red cell deformability, splenic function and anaemia in thalassaemia
Abstract
Red cell deformability (RCD) was measured in 38 patients with α- thalassaemia and 48 patients with β-thalassaemia, of whom 13 had undergone splenectomy. All splenectomized patients, but none of those with intact spleens, had very rigid erythrocytes with an elongation index <0.45 at a high shear stress of 30 Pa suggesting a splenic recognition threshold for removal of rigid red cells. At this shear stress RCD correlated strongly with the degree of anaemia in both the splenectomized (r = 0.81, P < 0.001) and non- splenectomized β-thalassaemic patients (all patients r=0.81, P<0.001; homozygous β-thalassaemic patients r= 0.51, P= 0.01). These data suggest that reduced RCD is a major determinant of anaemia in thalassaemia.