Publication: The effects of Salacia reticulata on anti-cellular oxidants and melanogenesis inhibition in α-MSH-stimulated and UV irradiated B16 melanoma cells
Issued Date
2014-01-01
Resource Type
ISSN
15559475
1934578X
1934578X
Other identifier(s)
2-s2.0-84898805854
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.9, No.4 (2014), 551-554
Suggested Citation
Prasit Suwannalert, Ryusho Kariya, Ikuko Suzu, Seiji Okada The effects of Salacia reticulata on anti-cellular oxidants and melanogenesis inhibition in α-MSH-stimulated and UV irradiated B16 melanoma cells. Natural Product Communications. Vol.9, No.4 (2014), 551-554. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33125
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Title
The effects of Salacia reticulata on anti-cellular oxidants and melanogenesis inhibition in α-MSH-stimulated and UV irradiated B16 melanoma cells
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Abstract
The purposes of this study were to investigate the inhibitory effects of Salacia reticulata Tul. root extract on cellular oxidants and melanogenesis in B16 melanoma cells. Cells treated with non-toxic doses of S. reticulata root extract were investigated for their effects on melanogenesis, cellular tyrosinase activity and cellular oxidant scavenging activity. The results indicated that S. reticulata extract inhibited melanin synthesis and tyrosinase activity in α-MSH-induced or UV-irradiated B16 melanoma cells in a dose dependent manner. Additionally, the extract also exhibited anti-cellular oxidants in UV-induced radical melanoma cells. Altogether, these results suggested that S. reticulata root extract has roles in suppression of melanogenesis and oxidant inhibition. S. reticulata root extract may be a potential source for the development of pharmaceutical products for treatment of skin hyperpigmentation disorders.