Publication:
Modification of relative potencies of beta-adrenoceptor agonists by negative chronotropic agents in rat atrium

Issued Date

1977-01-01

Resource Type

Article

ISSN

03063623

DOI

10.1016/0306-3623(77)90024-6

Other identifier(s)

2-s2.0-49349132222

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

General Pharmacology. Vol.8, No.4 (1977), 263-267

Suggested Citation

Chiravat Sadavongvivad, Jutamaad Satayavivad, Virapong Prachayasittikul, Ladda Mo-Suwun Modification of relative potencies of beta-adrenoceptor agonists by negative chronotropic agents in rat atrium. General Pharmacology. Vol.8, No.4 (1977), 263-267. doi:10.1016/0306-3623(77)90024-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10333

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Title

Modification of relative potencies of beta-adrenoceptor agonists by negative chronotropic agents in rat atrium

Author(s)

Chiravat Sadavongvivad
 Jutamaad Satayavivad
 Virapong Prachayasittikul
 Ladda Mo-Suwun

Other Contributor(s)

Mahidol University

Abstract

1. 1. Lowering temperature reduced maximal effects of all four common adrenoceptor agonists without any change in their potencies. 2. 2. Quinidine reduced their potencies slightly and lowered maximal effects only at high concentrations. 3. 3. Adenosine caused a large decrease in potency of isoprenaline but hardly affected that of phenylephrine. 4. 4. These and our previous results indicate that some endogeneous negative chronotropic agents can alter relative potencies of the agonists as well as characteristics of blockers. © 1977.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/10333

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Scopus 1969-1990