Publication: Long-term follow-up of myasthenia gravis patients with hyperthyroidism
Issued Date
2002-08-12
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ISSN
00016314
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2-s2.0-0036325703
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Mahidol University
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SCOPUS
Bibliographic Citation
Acta Neurologica Scandinavica. Vol.106, No.2 (2002), 93-98
Suggested Citation
D. Ratanakorn, A. Vejjajiva Long-term follow-up of myasthenia gravis patients with hyperthyroidism. Acta Neurologica Scandinavica. Vol.106, No.2 (2002), 93-98. doi:10.1034/j.1600-0404.2002.01191.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20410
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Title
Long-term follow-up of myasthenia gravis patients with hyperthyroidism
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Abstract
Objective - To access clinical characteristics and treatment outcome of myasthenia gravis (MG) patients with hyperthyroidism (HT). Materials and methods - The clinical characteristics of 51 MG patients with HT were studied. The treatment outcome was analysed in 34 patients, comparing high-dosage prednisolone (HDP) (group IS), HDP and/or immunosuppressants with antithyroid drugs (group IS + antiHThyr), antithyroid drugs (group antiHThyr), and thymectomy. Results - The prevalence of HT in MG was 17.5%. Group IS showed higher remission of both diseases compared with group antiHThyr, but not with group IS + antiHThyr. Remission of HT and relapse of both diseases showed no difference among the three groups. Ten patients who had thymectomies had a lower relapse of MG but not of HT, whilst remission of both diseases was no different to 24 non-thymectomy patients. Conclusion - This study showed a high prevalence of HT in Thai MG. HDP alone can induce remission of both diseases without difference in relapse. Thymectomy lowers MG relapse further but has no influence on HT.