Publication: MULTI-SITE INTRADERMAL AND MULTI-SITE SUBCUTANEOUS RABIES VACCINATION: IMPROVED ECONOMICAL REGIMENS
Issued Date
1984-04-21
Resource Type
ISSN
01406736
Other identifier(s)
2-s2.0-0021253208
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Lancet. Vol.323, No.8382 (1984), 874-876
Suggested Citation
M. J. Warrell, K. G. Nicholson, Pornthep Chanthavanich, Abha Sinhaseni, C. Xueref, Pravan Suntharasamai, D. A. Warrell, Chaisin Viravan, Rod Phanfung, J. C. Vincent-Falquet MULTI-SITE INTRADERMAL AND MULTI-SITE SUBCUTANEOUS RABIES VACCINATION: IMPROVED ECONOMICAL REGIMENS. The Lancet. Vol.323, No.8382 (1984), 874-876. doi:10.1016/S0140-6736(84)91340-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30664
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Title
MULTI-SITE INTRADERMAL AND MULTI-SITE SUBCUTANEOUS RABIES VACCINATION: IMPROVED ECONOMICAL REGIMENS
Abstract
Neutralising antibody responses to six post-exposure regimens of human diploid cell strain rabies vaccine with or without human rabies immune globulin (HRIG) were studied in 98 patients. The total amount of vaccine used was 22-34% of that required by conventional regimens. Vaccine was given at multiple sites intradermally or subcutaneously with or without adjuvant. Antibody was detectable within 7 days of the first dose in all subjects only in the groups given 0·1 ml intradermally at 8 sites. From day 14 onwards all groups showed an excellent antibody response; there was little difference between the various regimens. Suppression of the response to 8-site intradermal vaccination by a large dose of HRIG could be prevented by giving the second dose of vaccine on day 7 rather than day 14. © 1984.